INTEGRA
Integrated External and Internal Exposure to Chemicals
The objective of INTEGRA is to bring together all available information within a coherent methodological framework for assessing the source-to-dose continuum for the entire life cycle of substances covering an extensive chemical space. Hence, the major component of INTEGRA will be a unified computational platform that integrates environmental fate, exposure and internal dose dynamically in time. In this way, the platform will be able to differentiate between biomonitoring data corresponding to steady exposure patterns as opposed to acute, one-off exposures. The platform will be largely validated using human biomonitoring data from Europe and the USA. The INTEGRA computational platform will be based on the existing platform developed in the frame of the LRI-B4 INTERA and LRI-B5 TAGS projects extending it to incorporate several advances: